PICKLS STORIES
MEDICAL
Hollywood Celebs' Secret, Renuva vs K-Beauty's New Wave, Elravie Re2O! What's the optimal choice for your skin?
Written by: Dr. Yeseul Moon / Published on: 2025-07-19

Hello, this is PICKLS, always keeping an eye on the forefront of skin trends.
Today, we're going to do an in-depth comparative analysis of two premium skin solutions that are hot topics in the global beauty market: 'Renuva' and 'Elravie Re2O®,' which was recently ambitiously launched in Korea.
Renuva, known as the secret to Hollywood celebrities' firm skin, and Re2O, set to lead K-beauty innovation!
So, what are the differences between them?
1.
✨ Ingredients and Manufacturing Process: The Difference That Truly Fills the Skin
Both products focus on 'collagen regeneration', but there are interesting differences in their methods.
Renuva: Renuva is a procedure gaining attention as an alternative to 'autologous fat grafting'. It promotes collagen production using components extracted from 'donated adipose tissue' without the need for fat harvesting. It primarily consists of 'growth factors' and 'extracellular matrix (ECM)' components that induce collagen production in the skin after fat grafting, rather than fat cells themselves. In other words, it is injected into sunken areas to activate collagen regeneration within the skin, helping to create natural volume and improve skin elasticity. Although it uses fat-derived components, it offers high procedural convenience as it doesn't require harvesting one's own fat.
Elravie Re2O: This is where K-beauty's innovation shines! Re2O's main ingredient is 'human Acellular Dermal Matrix (hADM)', which is made by removing the epidermis and fat from human skin tissue and sterilizing it. Simply put, it directly injects 'extracellular matrix (ECM)' components such as collagen, elastin, and hyaluronic acid that constitute the dermal layer of actual human skin. Being a human-derived ingredient, it boasts excellent biocompatibility and has proven its safety and efficacy through AATB, MFDS, and FDA raw material approvals. It is composed of 89% collagen, 3% elastin, 0.4% GAG including hyaluronic acid, and 7.6% other ECM components.
The manufacturing process involves refining ADM by removing the epidermis and fat from human skin tissue, then micronizing it to create Re2O. The patented AlloClean Technology is said to minimize residual DNA and maintain the native ECM matrix structure of the human body, showing excellent effects in new ECM formation.
2.
🌱 Pros and Cons: A Wise Choice Tailored to My Needs
Renuva
Advantages: There is less burden for the procedure as self-fat harvesting is unnecessary. It induces natural collagen production, so you can expect non-artificial volume improvement and skin regeneration effects. It is particularly said to be effective for improving thin skin layers or fine wrinkles.
Disadvantages: As it is a donated fat-derived ingredient, allergic reactions may rarely occur, and it may take time for collagen to form, so the effect may be slow to appear. Bruising, swelling, etc., may occur depending on the injection site.
Elravie Re2O®
Advantages: It directly injects actual skin ECM components to induce immediate micro-volume effects and fundamental skin regeneration. An increase in collagen density by 2.9 times and elastin density by 3.2 times has been confirmed, and it is said that the effect is maintained even after 6 months. Improvement effects have been confirmed in various indicators such as pore size improvement by about 26.9%, blemish/spot improvement by about 11.5%, skin texture density improvement by about 9%, melanin reduction, and collagen power increase. While the maintenance period of typical skin boosters is 3-6 months, Rejuve shows effects for more than 1 year. Superior wrinkle improvement effects compared to other skin boosters have also been confirmed.
Disadvantages: Temporary swelling, bruising, micro-nodules, etc., may appear after injection. (Most are said to disappear within 24-48 hours.)
3.
💉 Procedure Method and Effect: What's the Difference?
Renuva: It is mainly injected into sunken areas of the skin or areas with fine wrinkles using a cannula. Similar to fat grafting, it fills volume and then induces collagen production to improve skin elasticity.
Elravie Re2O®:: It is recommended to inject into the Deep Dermis of the face (excluding the eye area) and neck wrinkles at an angle of 45~60∘ using a 30~32G 4mm needle. Injectors such as DermaShine Pro can also be used, and in addition to standalone procedures, it can also be mixed with hyaluronic acid (HA) skin boosters for the procedure.
It is said that blood circulation improvement and skin barrier improvement effects appear from 3 days after the procedure, and overall effects such as pore reduction, fine wrinkle improvement, and skin texture improvement can be experienced from 1-2 weeks after. Ultimately, it resolves the fundamental causes of skin aging and improves it to firm and healthy skin. The procedure takes about 10 minutes.
4.
🚨 Side Effects and Precautions:
For a safe and wise procedure
Renuva: Allergic reactions are rare as it is derived from donated tissue, but bruising, swelling, pain, and infection may occur at the treatment site. In rare cases, nodules may develop in the injected area.
Elravie Re2O®:: Temporary bruising or swelling may occur due to the injection, and temporary edema, erythema, and micro-nodules may occur after the procedure.
5.
Renuva can be an attractive option for those who want natural volume improvement and collagen regeneration without the burden of autologous fat grafting. On the other hand, Ellavie Re2O® can be said to have opened new horizons in that it directly fills 'real skin ECM components' to expect not only immediate micro-volume but also fundamental skin regeneration and long-term effects. In particular, if you are concerned about fine wrinkles, loss of elasticity, enlarged pores, or uneven skin tone due to skin aging, Ellavie Re2O® could be a wise choice for your skin.
What is most important is to determine the most suitable procedure for you by fully consulting with medical staff about your individual skin condition, concerns, and expectations for the procedure. We hope the information PICKLS shared today has been helpful in making a wise choice for your beauty. If you have any further questions or need assistance, please feel free to contact the PICKLS team at any time!